Transgenics is the term used by the Ordinaries for the X-series and the Anomalies. Transgenics originate from a secret genetic engineering program founded by Dr. Sandeman with the intention of finding a way to save the human race from The Coming, but taken over by the Committee and corrupted into a black-ops military project that evolved into Project Manticore.
After Ames White publically admitted the existance of Transgenics, humans began a crazed hunt to catch and kill all transgenics. The transgenics took refuge within Terminal City.
